Effect of co-administered inducer or inhibitor on omeprazole pharmacokinetics based on CYP2C19 genotype

• Main Authors: Chiaki Kamiya (Author), Naoki Inui (Author), Akio Hakamata (Author), Sachiko Miyakawa (Author), Shimako Tanaka (Author), Shinya Uchida (Author), Noriyuki Namiki (Author), Keiichi Odagiri (Author), Hiroshi Watanabe (Author)
• 格式: 圖書
• 出版: Elsevier, 2019-04-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Polymorphisms of cytochrome P450 (CYP) enzymes can affect enzymatic activity, drug metabolism and drug interactions. Although the potential for drug interactions is especially important when co-administering drugs with strong inductive or inhibitory potential towards drug-metabolizing enzymes, the r...