The orphan nuclear receptor EAR-2 (NR2F6) inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo

• Main Authors: Christine V. Ichim (Author), Dzana D. Dervovic (Author), Lap Shu Alan Chan (Author), Claire J. Robertson (Author), Alden Chesney (Author), Marciano D. Reis (Author), Richard A. Wells (Author)
• 格式: 图书
• 出版: BMC, 2018-12-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Abstract Background In patients with myelodysplastic syndrome (MDS), bone marrow cells have an increased predisposition to apoptosis, yet MDS cells outcompete normal bone marrow (BM)-- suggesting that factors regulating growth potential may be important in MDS. We previously identified v-Erb A relat...