CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections

• Main Authors: Mark R. Cronan (Author), Allison F. Rosenberg (Author), Stefan H. Oehlers (Author), Joseph W. Saelens (Author), Dana M. Sisk (Author), Kristen L. Jurcic Smith (Author), Sunhee Lee (Author), David M. Tobin (Author)
• Format: Book
• Published: The Company of Biologists, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been used to directly observe infection in vivo; however, such larvae have not yet developed a functional adaptive immune system. Cells involved i...