Recombinant antigens expressed in Pichia pastoris for the diagnosis of sleeping sickness caused by Trypanosoma brucei gambiense.

Recombinant antigens expressed in Pichia pastoris for the diagnosis of sleeping sickness caused by Trypanosoma brucei gambiense.

Screening tests for gambiense sleeping sickness, such as the CATT/T. b. gambiense and a recently developed lateral flow tests, are hitherto based on native variant surface glycoproteins (VSGs), namely LiTat 1.3 and LiTat 1.5, purified from highly virulent trypanosome strains grown in rodents.We have...

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Main Authors: Stijn Rogé (Author), Liesbeth Van Nieuwenhove (Author), Magali Meul (Author), Annick Heykers (Author), Annette Brouwer de Koning (Author), Nicolas Bebronne (Author), Yves Guisez (Author), Philippe Büscher (Author)
Format: Book
Published: Public Library of Science (PLoS), 2014-07-01T00:00:00Z.
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