Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing

• Main Authors: Irene A. Stafford (Author), Fernando H. Centeno (Author), Mayar Al Mohajer (Author), George Parkerson (Author), Laila Woc-Colburn (Author), Angelica Janice Burgos-Lee (Author), Martha Rac (Author), James Dunn (Author), Kenneth Muldrew (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flea-borne (murine) typhus is caused by Rickettsia typhi. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitte...