Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells

• Main Authors: Corinne Hamblet (Author), Karin Björhall (Author), Susann Busch (Author), Ulf Gehrmann (Author), Lisa Öberg (Author), Rebekka Kubisch-Dohmen (Author), Sonja Haas (Author), Manish K. Aneja (Author), Johannes Geiger (Author), Carsten Rudolph (Author), Ellinor Hornberg (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive pathology in a number of lung diseases. Cellular damage caused by oxidative damage is reversed by several pathways, one of which is the antioxidant r...