Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response

• 主要な著者: Nicolas Floc'h (著者), Maria Luisa Guerriero (著者), Antonio Ramos-Montoya (著者), Barry R. Davies (著者), Jonathan Cairns (著者), Natasha A. Karp (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2018-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The high attrition rate of preclinical agents entering oncology clinical trials has been associated with poor understanding of the heterogeneous patient response, arising from limitations in the preclinical pipeline with cancer models. Patient-derived tumor xenograft (PDX) models have been shown to...