Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

• Main Authors: Allison C. Sharrow (Author), Emily Megill (Author), Amanda J. Chen (Author), Afifa Farooqi (Author), Naveen Kumar Tangudu (Author), Apoorva Uboveja (Author), Stacy McGonigal (Author), Nadine Hempel (Author), Nathaniel W. Snyder (Author), Ronald J. Buckanovich (Author), Katherine M. Aird (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Quiescence is a reversible cell cycle exit traditionally thought to be associated with a metabolically inactive state. Recent work in muscle cells indicates that metabolic reprogramming is associated with quiescence. Whether metabolic changes occur in cancer to drive quiescence is unclear. Using a m...