GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein

• Main Authors: Simon Hoffman (Author), Danielle Alvares (Author), Khosrow Adeli (Author)
• Format: Bog
• Udgivet: Elsevier, 2022-11-01T00:00:00Z.
• Fag: article
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Background/Objective: GLP-1R agonists have been shown to reduce fasting and postprandial plasma lipids, both of which are independent risk factors for the development of cardiovascular disease. However, how endogenous GLP-1 - which is rapidly degraded - modulates intestinal and hepatic lipid metabol...