Inducing CCR5Δ32/Δ32 Homozygotes in the Human Jurkat CD4+ Cell Line and Primary CD4+ Cells by CRISPR-Cas9 Genome-Editing Technology

• मुख्य लेखकों: Chunxia Qi (लेखक), Dan Li (लेखक), Xiangxiang Jiang (लेखक), Xiaopeng Jia (लेखक), Lingling Lu (लेखक), Yanfeng Wang (लेखक), Jinhuan Sun (लेखक), Yiming Shao (लेखक), Min Wei (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2018-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

C-C chemokine receptor type 5 (CCR5) is the main co-receptor for HIV entry into the target CD4+ cells, and homozygous CCR5Δ32/Δ32 cells are resistant to CCR5-tropic HIV infection. However, the CCR5Δ32/Δ32 homozygous donors in populations are rare. Here we developed a simple approach to induce CCR5Δ3...