Evaluation of Silybin Nanoparticles against Liver Damage in Murine <i>Schistosomiasis mansoni</i> Infection

• Main Authors: Daniel Figueiredo Vanzan (Author), Ester Puna Goma (Author), Fernanda Resende Locatelli (Author), Thiago da Silva Honorio (Author), Priscila de Souza Furtado (Author), Carlos Rangel Rodrigues (Author), Valeria Pereira de Sousa (Author), Hilton Antônio Mata dos Santos (Author), Flávia Almada do Carmo (Author), Alice Simon (Author), Alexandre dos Santos Pyrrho (Author), António José Ribeiro (Author), Lucio Mendes Cabral (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Silybin (SIB) is a hepatoprotective drug known for its poor oral bioavailability, attributed to its classification as a class IV drug with significant metabolism during the first-pass effect. This study explored the potential of solid lipid nanoparticles with (SLN-SIB-U) or without (SLN-SIB) ursodeo...