Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen

• Main Authors: Lena Klopp-Schulze (Author), Anna Mueller-Schoell (Author), Patrick Neven (Author), Stijn L. W. Koolen (Author), Ron H. J. Mathijssen (Author), Markus Joerger (Author), Charlotte Kloft (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionAt tamoxifen standard dosing, ∼20% of breast cancer patients do not reach proposed target endoxifen concentrations >5.97 ng/mL. Thus, better understanding the large interindividual variability in tamoxifen pharmacokinetics (PK) is crucial. By applying non-linear mixed-effects (NLME) m...