RNA Structure Design Improves Activity and Specificity of trans-Splicing-Triggered Cell Death in a Suicide Gene Therapy Approach

Spliceosome-mediated RNA trans-splicing enables correction or labeling of pre-mRNA, but therapeutic applications are hampered by issues related to the activity and target specificity of trans-splicing RNA (tsRNA). We employed computational RNA structure design to improve both on-target activity and...

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Main Authors: Sushmita Poddar (Author), Pei She Loh (Author), Zi Hao Ooi (Author), Farhana Osman (Author), Joachim Eul (Author), Volker Patzel (Author)
Format: Book
Published: Elsevier, 2018-06-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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