RNA Structure Design Improves Activity and Specificity of trans-Splicing-Triggered Cell Death in a Suicide Gene Therapy Approach
Spliceosome-mediated RNA trans-splicing enables correction or labeling of pre-mRNA, but therapeutic applications are hampered by issues related to the activity and target specificity of trans-splicing RNA (tsRNA). We employed computational RNA structure design to improve both on-target activity and...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2018-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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