Maternal obesity programs increased leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner

• Main Authors: Simon Lecoutre (Author), Frederik Oger (Author), Charlène Pourpe (Author), Laura Butruille (Author), Lucie Marousez (Author), Anne Dickes-Coopman (Author), Christine Laborie (Author), Céline Guinez (Author), Jean Lesage (Author), Didier Vieau (Author), Claudine Junien (Author), Delphine Eberlé (Author), Anne Gabory (Author), Jérôme Eeckhoute (Author), Christophe Breton (Author)
• Format: Book
• Published: Elsevier, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and accelerated growth in neonates predispose offspring to white adipose tissue (WAT) accumulation. In rodents, adipogenesis mainly develops during lactation. The mechanisms underlying the phenom...