Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

• Main Authors: Mikhail Krasavin (Author), Stanislav Kalinin (Author), Sergey Zozulya (Author), Anastasiia Gryniukova (Author), Petro Borysko (Author), Andrea Angeli (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The differential scanning fluorimetry (DSF) screening of 5.692 fragments in combination with benzenesulfonamide (BSA) against bovine carbonic anhydrase (bCA) delivered >100 hits that either caused, on their own, a significant thermal shift (ΔTm, °C) in the protein melting temperature or significa...