Investigation of factors that cause insulin precipitation and/or amyloid formation in insulin formulations

• Main Authors: Yui Ohno (Author), Tomohiro Seki (Author), Yu Kojima (Author), Ryotaro Miki (Author), Yuya Egawa (Author), Osamu Hosoya (Author), Keizo Kasono (Author), Toshinobu Seki (Author)
• Format: Book
• Published: BMC, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Multiple daily subcutaneous injections (MDSIs) are mainly used for formulating an insulin therapy for diabetic patients; however, they also cause insulin-derived amyloidosis (IDA) and lead to poor glycemic control. In addition, for the continuous subcutaneous insulin infusion sys...