A cross-reactive monoclonal antibody to nematode haemoglobin enhances protective immune responses to Nippostrongylus brasiliensis.

• Main Authors: Natalie E Nieuwenhuizen (Author), Jeanne M Meter (Author), William G Horsnell (Author), J Claire Hoving (Author), Lizette Fick (Author), Michael F Sharp (Author), Matthew G Darby (Author), Suraj P Parihar (Author), Frank Brombacher (Author), Andreas L Lopata (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Nematode secreted haemoglobins have unusually high affinity for oxygen and possess nitric oxide deoxygenase, and catalase activity thought to be important in protection against host immune responses to infection. In this study, we generated a monoclonal antibody (48Eg) against haemoglobi...