Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: a drug-target Mendelian randomization study

• Principais autores: Yilong Lin (Autor), Yue Zhang (Autor), Songsong Wang (Autor), Lin Cao (Autor), Ruidan Zhao (Autor), Xilai Ma (Autor), Qiaolu Yang (Autor), Liyi Zhang (Autor), Qingmo Yang (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BackgroundThe relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors and prostate cancer is still unknown. Although these inhibitors can influence tumor glycolysis, the underlying mechanism requires further exploration.MethodsA two-sample two-step MR was used to determine 1) causal e...