Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: a drug-target Mendelian randomization study

• Main Authors: Yilong Lin (Author), Yue Zhang (Author), Songsong Wang (Author), Lin Cao (Author), Ruidan Zhao (Author), Xilai Ma (Author), Qiaolu Yang (Author), Liyi Zhang (Author), Qingmo Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundThe relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors and prostate cancer is still unknown. Although these inhibitors can influence tumor glycolysis, the underlying mechanism requires further exploration.MethodsA two-sample two-step MR was used to determine 1) causal e...