Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis.

• Main Authors: Rubens L do Monte-Neto (Author), Adriano C Coelho (Author), Frédéric Raymond (Author), Danielle Légaré (Author), Jacques Corbeil (Author), Maria N Melo (Author), Frédéric Frézard (Author), Marc Ouellette (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Drug resistance is a major problem in leishmaniasis chemotherapy. RNA expression profiling using DNA microarrays is a suitable approach to study simultaneous events leading to a drug-resistance phenotype. Genomic analysis has been performed primarily with Old World Leishmania species and...