FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

• Main Authors: Shikshya Shrestha (Author), Woohyun Cho (Author), Benjamin Stump (Author), Jewel Imani (Author), Anthony M. Lamattina (Author), Pierce H. Louis (Author), James Pazzanese (Author), Ivan O. Rosas (Author), Gary Visner (Author), Mark A. Perrella (Author), Souheil El-Chemaly (Author)
• Format: Book
• Published: BMC, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage. Lymphatic vessel endothelial hyaluronan receptor (LYVE-1) expressed on the surface of lymphatic...