Effects of Hypothermia and Allopurinol on Oxidative Status in a Rat Model of Hypoxic Ischemic Encephalopathy

• Main Authors: Cristina Durán Fernández-Feijóo (Author), Javier Rodríguez-Fanjul (Author), Miriam Lopez-Abat (Author), Stephanie Hadley (Author), Mónica Cavia-Saiz (Author), Pilar Muñiz (Author), Juan Arnaez (Author), José Ramón Fernández-Lorenzo (Author), Marta Camprubí Camprubí (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxic ischemic encephalopathy (HIE) is one of the main causes of morbidity and mortality during the neonatal period, despite treatment with hypothermia. There is evidence that oxidative damage plays an important role in the pathophysiology of hypoxic-ischemic (HI) brain injury. Our aim was to inve...