ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids

• Main Authors: Rossella Menghini (Author), Lesley Hoyles (Author), Marina Cardellini (Author), Viviana Casagrande (Author), Arianna Marino (Author), Paolo Gentileschi (Author), Francesca Davato (Author), Maria Mavilio (Author), Ivan Arisi (Author), Alessandro Mauriello (Author), Manuela Montanaro (Author), Manuel Scimeca (Author), Richard H. Barton (Author), Francesca Rappa (Author), Francesco Cappello (Author), Manlio Vinciguerra (Author), José Maria Moreno-Navarrete (Author), Wifredo Ricart (Author), Ottavia Porzio (Author), José-Manuel Fer (Author), Rémy Burcelin (Author), Marc-Emmanuel Dumas (Author), Massimo Federici (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Metabolic syndrome, obesity, and steatosis are characterized by a range of dysregulations including defects in ubiquitin ligase tagging proteins for degradation. The identification of novel hepatic genes associated with fatty liver disease and metabolic dysregulation may be relevant to un...