Two novel C-terminal frameshift mutations in the β-globin gene lead to rapid mRNA decay

• Main Authors: Katarzyna Rawa (Author), Roman J. Szczesny (Author), Ewelina P. Owczarek (Author), Anna Adamowicz-Salach (Author), Anna Klukowska (Author), Urszula Demkow (Author), Danuta Plochocka (Author), Pawel Szczesny (Author), Monika Gora (Author), Andrzej Dziembowski (Author), Beata Burzynska (Author)
• Format: Book
• Published: BMC, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The thalassemia syndromes are classified according to the globin chain or chains whose production is affected. β-thalassemias are caused by point mutations or, more rarely, deletions or insertions of a few nucleotides in the β-globin gene or its immediate flanking sequences. Thes...