S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity.

• Main Authors: Fábio Mambelli (Author), Bruno P O Santos (Author), Suellen B Morais (Author), Enrico G T Gimenez (Author), Duana C Dos S Astoni (Author), Amanda D Braga (Author), Rafaela S Ferreira (Author), Flávio A Amaral (Author), Mariana T Q de Magalhães (Author), Sergio C Oliveira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Schistosoma mansoni SmKI-1 protein is composed of two domains: a Kunitz-type serine protease inhibitor motif (KD) and a C-terminus domain with no similarity outside the genera. Our previous work has demonstrated that KD plays an essential role in neutrophil elastase (NE) binding blockage, in neu...