RICTOR amplification is associated with Rictor membrane staining and does not correlate with PD-L1 expression in lung squamous cell carcinoma

• Main Authors: Ildikó Krencz (Author), Dániel Sztankovics (Author), Anna Sebestyén (Author), Judit Pápay (Author), Titanilla Dankó (Author), Dorottya Moldvai (Author), Elmar Lutz (Author), Andras Khoor (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RICTOR gene, which encodes the scaffold protein of mTORC2, can be amplified in various tumor types, including squamous cell carcinoma (SCC) of the lung. RICTOR amplification can lead to hyperactivation of mTORC2 and may serve as a targetable genetic alteration, including in lung SCC patients with no...