<i>POLRMT</i> as a Novel Susceptibility Gene for Cardiotoxicity in Epirubicin Treatment of Breast Cancer Patients

• Main Authors: Alejandro Velasco-Ruiz (Author), Rocio Nuñez-Torres (Author), Guillermo Pita (Author), Hans Wildiers (Author), Diether Lambrechts (Author), Sigrid Hatse (Author), Danielle Delombaerde (Author), Thomas Van Brussel (Author), M. Rosario Alonso (Author), Nuria Alvarez (Author), Belen Herraez (Author), Christof Vulsteke (Author), Pilar Zamora (Author), Teresa Lopez-Fernandez (Author), Anna Gonzalez-Neira (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anthracyclines are among the most used chemotherapeutic agents in breast cancer (BC). However their use is hampered by anthracycline-induced cardiotoxicity (AIC). The currently known clinical and genetic risk factors do not fully explain the observed inter-individual variability and only have a limi...