Cerium Oxide Nanoparticles Re-establish Cell Integrity Checkpoints and Apoptosis Competence in Irradiated HaCat Cells via Novel Redox-Independent Activity

• Hauptverfasser: Fanny Caputo (VerfasserIn), Anna Giovanetti (VerfasserIn), Francesca Corsi (VerfasserIn), Vittoria Maresca (VerfasserIn), Stefania Briganti (VerfasserIn), Silvia Licoccia (VerfasserIn), Enrico Traversa (VerfasserIn), Lina Ghibelli (VerfasserIn)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Cerium oxide nanoparticles (CNPs) are potent radical scavengers protecting cells from oxidative insults, including ionizing radiation. Here we show that CNPs prevent X-ray-induced oxidative imbalance reducing DNA breaks on HaCat keratinocytes, nearly abating mutagenesis. At the same time, and in spi...