Whole-Brain Three-Dimensional Profiling Reveals Brain Region Specific Axon Vulnerability in 5xFAD Mouse Model

• Main Authors: Jianping Zhang (Author), Ben Long (Author), Anan Li (Author), Qingtao Sun (Author), Jiaojiao Tian (Author), Ting Luo (Author), Zhangheng Ding (Author), Hui Gong (Author), Xiangning Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Axonopathy is a pathological feature observed in both Alzheimer's disease (AD) patients and animal models. However, identifying the temporal and regional progression of axonopathy during AD development remains elusive. Using the fluorescence micro-optical sectioning tomography system, we acquir...