Whole-Brain Three-Dimensional Profiling Reveals Brain Region Specific Axon Vulnerability in 5xFAD Mouse Model

• Glavni autori: Jianping Zhang (Autor), Ben Long (Autor), Anan Li (Autor), Qingtao Sun (Autor), Jiaojiao Tian (Autor), Ting Luo (Autor), Zhangheng Ding (Autor), Hui Gong (Autor), Xiangning Li (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Axonopathy is a pathological feature observed in both Alzheimer's disease (AD) patients and animal models. However, identifying the temporal and regional progression of axonopathy during AD development remains elusive. Using the fluorescence micro-optical sectioning tomography system, we acquir...