Mechanistic Modeling of Maternal Lymphoid and Fetal Plasma Antiretroviral Exposure During the Third Trimester

• Autori principali: Babajide Shenkoya (Autore), Shakir Atoyebi (Autore), Ibrahim Eniayewu (Autore), Abdulafeez Akinloye (Autore), Adeniyi Olagunju (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Pregnancy-induced changes in plasma pharmacokinetics of many antiretrovirals (ARV) are well-established. Current knowledge about the extent of ARV exposure in lymphoid tissues of pregnant women and within the fetal compartment is limited due to their inaccessibility. Subtherapeutic ARV concentration...