Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes

• Main Authors: Charlotte Berg Holt (Author), Jakob Appel Østergaard (Author), Esben Axelgaard (Author), Gitte Krogh Nielsen (Author), Yuichi Endo (Author), Steffen Thiel (Author), Troels Krarup Hansen (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. The innate immune system may have adverse effects in diabetes and cardiovascular disease. The complement system seems to play a key role through erroneous complement activation via hyperglycaemia-induced neoepitopes. Recently mannan-binding lectin (MBL) was shown to worsen diabetic kidne...