Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins

• Main Authors: Robin A. Lu (Author), Amir A. Zeki (Author), Sumati Ram-Mohan (Author), Nhan Nguyen (Author), Yan Bai (Author), Kenneth Chmiel (Author), Stevan Pecic (Author), Xingbin Ai (Author), Ramaswamy Krishnan (Author), Chandra C. Ghosh (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening bronchoconstriction. To fill this therapeutic gap, we examined a potential role for the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)...