A novel and efficient murine model of Bietti crystalline dystrophy

• Main Authors: Yafang Wang (Author), Yang Liu (Author), Shu Liu (Author), Xiaomeng Li (Author), Xinxin Liu (Author), Ming Jiao (Author), Yuqin Yang (Author), Xueting Luo (Author), Fenghua Wang (Author), Xiaoling Wan (Author), Xiaodong Sun (Author)
• Format: Book
• Published: The Company of Biologists, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease, resulting in blindness in most patients. The etiology and development mechanism of it remain unclear. Given the defects in previous mouse models of BCD, we generated a new Cyp4v3−/− mouse model, using CRISPR/Cas9...