Covalent targeting the LAS1-NOL9 axis for selective treatment in NPM1 mutant acute myeloid leukemia

• Päätekijät: Yefan Han (Tekijä), Anni Hu (Tekijä), Yi Qu (Tekijä), Qianqian Xu (Tekijä), Hang Wang (Tekijä), Yin Feng (Tekijä), Yili Hu (Tekijä), Li He (Tekijä), Hao Wu (Tekijä), Xinzhi Wang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2023-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Patients with NPM1 gene mutation-associated acute myeloid leukemia (AML), particularly those over the age of 60, have no viable targeted therapeutic choices. In this study, we identified HEN-463, a sesquiterpene lactone derivative specific targets AML with this gene mutation. This compound inhibits...