Covalent targeting the LAS1-NOL9 axis for selective treatment in NPM1 mutant acute myeloid leukemia

• Main Authors: Yefan Han (Author), Anni Hu (Author), Yi Qu (Author), Qianqian Xu (Author), Hang Wang (Author), Yin Feng (Author), Yili Hu (Author), Li He (Author), Hao Wu (Author), Xinzhi Wang (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with NPM1 gene mutation-associated acute myeloid leukemia (AML), particularly those over the age of 60, have no viable targeted therapeutic choices. In this study, we identified HEN-463, a sesquiterpene lactone derivative specific targets AML with this gene mutation. This compound inhibits...