Biodistribution of Intra-Arterial and Intravenous Delivery of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Rat Model to Guide Delivery Strategies for Diabetes Therapies

• Main Authors: Junfeng Li (Author), Hirotake Komatsu (Author), Erasmus K. Poku (Author), Tove Olafsen (Author), Kelly X. Huang (Author), Lina A. Huang (Author), Junie Chea (Author), Nicole Bowles (Author), Betty Chang (Author), Jeffrey Rawson (Author), Jiangling Peng (Author), Anna M. Wu (Author), John E. Shively (Author), Fouad R. Kandeel (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-MSC-EVs) have become an emerging strategy for treating various autoimmune and metabolic disorders, particularly diabetes. Delivery of UC-MSC-EVs is essential to ensure optimal efficacy of UC-MSC-EVs. To develop safe and superior...