Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support

• Main Authors: Maria Pérez Marín (Author), Sylvain Prod'hom (Author), Suzanne Francesca de Villiers (Author), Thomas Ferry (Author), Vivianne Amiet (Author), Julia Natterer (Author), Maria-Helena Perez (Author), Thierry Buclin (Author), Haithem Chtioui (Author), David Longchamp (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal. At therapeutic concentrations, colchicine elimination occurs mainly through hepatic metabolism...