Effect of Dornase Alfa on the Lung Clearance Index in Children with Cystic Fibrosis: A Lesson from a Case Series

• Main Authors: Vito Terlizzi (Author), Giuseppe Fabio Parisi (Author), Beatrice Ferrari (Author), Chiara Castellani (Author), Sara Manti (Author), Salvatore Leonardi (Author), Giovanni Taccetti (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Dornase alfa (DNase) is the only mucus-degrading agent that has proven efficacy in cystic fibrosis (CF). Few studies have evaluated the effects of DNase on the lung clearance index (LCI). We report the experience of two CF centers in which LCI monitoring was used to evaluate the efficacy...