Helicobacter pylori eradication induce platelet recovery in idiopathic thrombocytopenic purpura
Recent reports have suggested an association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (1TP). The prevalence of H pylori infection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 pati...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Livre |
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PAGEPress Publications,
2001-12-01T00:00:00Z.
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| Résumé: | Recent reports have suggested an association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (1TP). The prevalence of H pylori infection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 x IO^L-120 x IO'VL) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pylori infection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a non immunosuppressive treatment in some ITP patients. (Blood 2001; 97: 812-814) |
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| Description: | 10.4081/reumatismo.2001.330 0048-7449 2240-2683 |