Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia

• Main Authors: Hong Fan (Author), Zhe Chen (Author), Hai‐Bin Tang (Author), Le‐Qun Shan (Author), Zi‐Yi Chen (Author), Xiao‐Hui Wang (Author), Da‐Geng Huang (Author), Shi‐Chang Liu (Author), Xun Chen (Author), Hao Yang (Author), Dingjun Hao (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Transplantation of olfactory ensheathing cells (OECs) has been demonstrated to be beneficial for spinal cord injury (SCI) by modulating neuroinflammation, supporting neuronal survival and promoting angiogenesis. Besides OECs, the conditioned medium (CM) from OECs has also been proved to hav...