Protein methyltransferase 7 deficiency in Leishmania major increases neutrophil associated pathology in murine model.

• Main Authors: Juliana Alcoforado Diniz (Author), Mariana M Chaves (Author), Slavica Vaselek (Author), Rubens D Miserani Magalhães (Author), Rafael Ricci-Azevedo (Author), Renan V H de Carvalho (Author), Lucas B Lorenzon (Author), Tiago R Ferreira (Author), Dario Zamboni (Author), Pegine B Walrad (Author), Petr Volf (Author), David L Sacks (Author), Angela K Cruz (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania major is the main causative agent of cutaneous leishmaniasis in the Old World. In Leishmania parasites, the lack of transcriptional control is mostly compensated by post-transcriptional mechanisms. Methylation of arginine is a conserved post-translational modification executed by Protein...