Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington's disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters the physical structure of the mutant protein an...

Full description

Saved in:
Bibliographic Details
Main Authors: Baehyun Shin (Author), Roy Jung (Author), Hyejin Oh (Author), Gwen E. Owens (Author), Hyeongseok Lee (Author), Seung Kwak (Author), Ramee Lee (Author), Susan L. Cotman (Author), Jong-Min Lee (Author), Marcy E. MacDonald (Author), Ji-Joon Song (Author), Ravi Vijayvargia (Author), Ihn Sik Seong (Author)
Format: Book
Published: Elsevier, 2018-06-01T00:00:00Z.
Subjects:
article
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available

Similar Items