Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

• Główni autorzy: Baehyun Shin (Autor), Roy Jung (Autor), Hyejin Oh (Autor), Gwen E. Owens (Autor), Hyeongseok Lee (Autor), Seung Kwak (Autor), Ramee Lee (Autor), Susan L. Cotman (Autor), Jong-Min Lee (Autor), Marcy E. MacDonald (Autor), Ji-Joon Song (Autor), Ravi Vijayvargia (Autor), Ihn Sik Seong (Autor)
• Format: Książka
• Wydane: Elsevier, 2018-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington's disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters the physical structure of the mutant protein an...