Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

• Main Authors: Baehyun Shin (Author), Roy Jung (Author), Hyejin Oh (Author), Gwen E. Owens (Author), Hyeongseok Lee (Author), Seung Kwak (Author), Ramee Lee (Author), Susan L. Cotman (Author), Jong-Min Lee (Author), Marcy E. MacDonald (Author), Ji-Joon Song (Author), Ravi Vijayvargia (Author), Ihn Sik Seong (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington's disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters the physical structure of the mutant protein an...