In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma

• Main Authors: Solveig Lemmel (Author), Markus Weckmann (Author), Anna Wohlers (Author), Adan Chari Jirmo (Author), Ruth Grychtol (Author), Isabell Ricklefs (Author), Gyde Nissen (Author), Anna Bachmann (Author), Shantanu Singh (Author), Juan Caicedo (Author), Thomas Bahmer (Author), Gesine Hansen (Author), Erika Von Mutius (Author), Klaus F. Rabe (Author), Oliver Fuchs (Author), Anna-Maria Dittrich (Author), Bianca Schaub (Author), Christine Happle (Author), Anne E. Carpenter (Author), Matthias Volkmar Kopp (Author), Tim Becker (Author), the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL) (Author), Mustafa Abdo (Author), Miguel Alcazar (Author), Mira Berbig (Author), Heike Biller (Author), Xenia Bovermann (Author), Folke Brinkmann (Author), Mifflin-Rae Calveron (Author), David S. DeLuca (Author), Gesa Diekmann (Author), Christian Dopfer (Author), Markus Ege (Author), Svenja Foth (Author), Svenja Gaedcke (Author), Karoline I. Gaede (Author), Anika Habener (Author), Christian Herzmann (Author), Alexander Hose (Author), Sabina Illi (Author), Anne-Marie Kirsten (Author), Naschla Kohistani-Greif (Author), Inke R. König (Author), Silke Van Koningsbruggen-Rietschel (Author), Matthias V. Kopp (Author), Johanna Kurz (Author), Katja Landgraf-Rauf (Author), Kristina Laubhahn (Author), Lena Liboschik (Author), Claudia Liebl (Author), Berrit Liselotte Husstedt (Author), Bin Liu (Author), Nicole Maison (Author), Aydin Malik (Author), Carola Marzi (Author), Meike Meyer (Author), Catharina Nitsche (Author), Frauke Pedersen (Author), Mareike Price (Author), Harald Renz (Author), Ernst Rietschel (Author), Barbara Roesler (Author), Christina Schauberger (Author), Tom Schildberg (Author), Carsten Schmidt-Weber (Author), Nicolaus Schwerk (Author), Chrysanthi Skevaki (Author), Alena Steinmetz (Author), Laila Sultansei (Author), Marlen Szewczyk (Author), Dominik Thiele (Author), Vera Veith (Author), Gesche Voigt (Author), Benjamin Waschki (Author), Henrik Watz (Author), Stefanie Weber (Author), Nils Welchering (Author), Esther Zeitlmann (Author), Ulrich Zissler (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation. Previously, we found neutrophil granulocytes (NGs) from asthmatics exhibit decreased chemotaxis towards...