Val16A SOD2 Polymorphism Promotes Epithelial-Mesenchymal Transition Antagonized by Muscadine Grape Skin Extract in Prostate Cancer Cells

• Autori principali: Janae D. Sweeney (Autore), Marija Debeljak (Autore), Stacy Riel (Autore), Ana Cecilia Millena (Autore), James R. Eshleman (Autore), Channing J. Paller (Autore), Valerie Odero-Marah (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Epithelial-mesenchymal transition (EMT), a key event in cancer metastasis, allows polarized epithelial cells to assume mesenchymal morphologies, enhancing invasiveness and migration, and can be induced by reactive oxygen species (ROS). Val16A (Ala) SOD2 polymorphism has been associated with increase...