Fast and Sensitive Method for Simultaneous Quantification of Meropenem and Vaborbactam in Human Plasma Microsamples by Liquid Chromatography-Tandem Mass Spectrometry for Therapeutic Drug Monitoring

• Autores principales: Rossella Barone (Autor), Matteo Conti (Autor), Beatrice Giorgi (Autor), Milo Gatti (Autor), Pier Giorgio Cojutti (Autor), Pierluigi Viale (Autor), Federico Pea (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Meropenem (MRP)-Vaborbactam (VBR) is a novel beta-lactam/beta-lactamase inhibitor used for the management of difficult-to-treat Gram-negative infections. Among critically ill patients, MRP-VBR shows remarkable inter-individual variability in pharmacokinetic behavior, thus justifying the implementati...