Structure of Lacticaseicin 30 and Its Engineered Variants Revealed an Interplay between the N-Terminal and C-Terminal Regions in the Activity against Gram-Negative Bacteria

• Main Authors: Désiré Madi-Moussa (Author), Barbara Deracinois (Author), Radja Teiar (Author), Yanyan Li (Author), Marius Mihasan (Author), Christophe Flahaut (Author), Sylvie Rebuffat (Author), Françoise Coucheney (Author), Djamel Drider (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lacticaseicin 30 is one of the five bacteriocins produced by the Gram-positive <i>Lacticaseibacillus paracasei</i> CNCM I-5369. This 111 amino acid bacteriocin is noteworthy for being active against Gram-negative bacilli including <i>Escherichia coli</i> strains resistant to...