Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors

• Main Authors: Tomohiko Irie (Author), Yuta Yanase (Author), Yosuke Demizu (Author), Makoto Usami (Author), Ruri Kikura-Hanajiri (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine). The recreational methoxetamine use can cause several toxici...