Population pharmacokinetics of total and unbound valemetostat and platelet dynamics in healthy volunteers and patients with non‐Hodgkin lymphoma

• Main Authors: Masato Fukae (Author), Kyle Baron (Author), Masaya Tachibana (Author), John Mondick (Author), Takako Shimizu (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2024-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Valemetostat is an EZH2/1 inhibitor that has been approved in Japan for the treatment of patients with relapsed/refractory adult T‐cell leukemia/lymphoma, based mainly on results from a single‐arm phase II trial. It is currently under investigation worldwide for the treatment of other non‐H...