Evaluation and Validation of the Limited Sampling Strategy of Polymyxin B in Patients with Multidrug-Resistant Gram-Negative Infection

• Main Authors: Xueyong Li (Author), Bingqing Zhang (Author), Yu Cheng (Author), Maohua Chen (Author), Hailing Lin (Author), Binglin Huang (Author), Wancai Que (Author), Maobai Liu (Author), Lili Zhou (Author), Qinyong Weng (Author), Hui Zhang (Author), Hongqiang Qiu (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polymyxin B (PMB) is the final option for treating multidrug-resistant Gram-negative bacterial infections. The acceptable pharmacokinetic/pharmacodynamic target is an area under the concentration-time curve across 24 h at a steady state (AUC_ss,24h) of 50-100 mg·h/L. The limite...