Landscape and significance of human super enhancer-driven core transcription regulatory circuitry

• Main Authors: Chenchen Feng (Author), Chao Song (Author), Yong Jiang (Author), Jun Zhao (Author), Jian Zhang (Author), Yuezhu Wang (Author), Mingxue Yin (Author), Jiang Zhu (Author), Bo Ai (Author), Qiuyu Wang (Author), Fengcui Qian (Author), Yuexin Zhang (Author), Desi Shang (Author), Jiaqi Liu (Author), Chunquan Li (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A core transcription regulatory circuitry (CRC) is an interconnected self-regulatory circuitry that is formed by a group of core transcription factors (TFs). These core TFs collectively regulate gene expression by binding not only to their own super enhancers (SEs) but also to the SEs of one another...