Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model

• Main Authors: Atsushi Sugiyama (Author), Yoshioki Satoh (Author), Akira Takahara (Author), Kentaro Ando (Author), Kai Wang (Author), Sachiko Honsho (Author), Yuji Nakamura (Author), Keitaro Hashimoto (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While aldosterone receptor blockers improve survival of patients with congestive heart failure, spironolactone and its derivatives were recently shown to block ether-a-go-go-related gene (HERG) channels and native IKs and IKr currents in guinea pig ventricular myocytes. In this study, we examined in...